Hydroxypropyl - β - cyclodextrin applications in the field of medicine

① increase water-soluble insoluble drugs

HP-β - CD soluble in water at room temperature solubility generally greater than 50 g/100mL can even reach 80 g/100mL above. When the concentration was less than 40%, good liquidity, viscosity less. For the pharmaceutical industry can improve the solubility of drugs without the use of organic solvents, surfactants and lipids. Insoluble Drug use it after the envelope can significantly increase water-soluble. Drug and HP-β - cyclodextrin complexes formed, the increase of its concentration and HP-β - CD concentration increase is linear.
② increased drug stability, improve drug bioavailability
     Drugs in the storage process, will be light, heat, humidity, and many other factors, directly affect the quality of medicines, therefore stability is an important indicator of the study. HP-β - cyclodextrin inclusion of the drug after the drug entered the hole, can play to prevent drug volatile, sublimation, oxidation and decomposition-see role.
Using HP-β - cyclodextrin inclusion of drug dissolution speed, quick release, and can increase the absorption of the drug organisms and will be beneficial to the drug bioavailability.
③ reduce drug side effects
     The insoluble drugs Tongxinluo merger conversion route of administration, can significantly reduce the toxicity of drugs on the body and irritation.
Hydroxypropyl - β - cyclodextrin can be used for oral drugs, injections, mucosal drug delivery system (including nasal, rectal, cornea, etc.), transdermal drug delivery system, lipophilic drugs targeting vector can be used as protein the protective agent and stabilizer.